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If you always require a short-term win, you will lose in the long-term. When the company is 100x the size it is today, the savings are quite substantial.

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Odds are low almost all startups will be 100x the size they are today. Most fail. Don't optimize prematurely.

True, but if you DO hit that magic growth factor, it'll probably be too late to make a change of such magnitude. Better to get optimization experimentation out of the way (relatively) early.

For nearly all businesses the cost of service hosting is going to be similar to the amount spent on snacks. This seems about as useful as optimizing the brand of cereal you buy.

...which you should, for it's the quality of life that counts :)

That's a great problem to have.

Pro: Can't make hot cakes fast enough.

Con: I wish I could switch ovens; a white one matches my kitchen's decor.

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