By multi-line edit do you mean multiple cursors at once? Does it have a fancy regular expressions generator to replace it? Otherwise that's a non-starter for me, simultaneous editing is too valuable.
Mostly I use it for quick renaming of variables, string fixes, and some structural changes in code.
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[0] - multiple cursors, at least in Emacs, can work off-screen too, but I don't like not seeing what's going on when I do changes.
However, I do like to point out that it's really just eye-candy for stuff I was already able to do in emacs. Previously, I would have used either keyboard macros or query-replace-regexp to do the same things.
Ctrl-F <search query> SelectAll <edit with multiple cursors>
Do it all the time.