It is not a simulation of humans.
We have zero indication there are rules at a higher level than the quantum or gravity. Like rules on what you ought to do in the bedroom.
Also earth nor humans were created by intelligence, just like how mineral crystals or fjords are not created by intelligence.
Hence we must conclude that bronze/iron age religions and maybe living in a simulator are not the same thing.
For the rest of this question of a creator, we cannot know, anybody claiming to know anything beyond "perhaps" or "maybe" is a fool, or will win a nobel price. By lack of the latter the rest of us will assume the first.
There is no difference.
Especially when such ideas are grounded in bronze age thinking.
"There is no difference." Indeed, if god exists or not, there is no difference ...
But what if it turns out this is a simulation by some extremist party, who want to see how to stack people against each other using religion? In that case we would owe it to the people there in the real world that we don't ...
Plus you can rest assured that that the sim master himself lives in a simulated universe, somebody else will hold his big button. Buttons all the way down.
From the pit of unknowable things, people can dredge up any coherent story. They might believe it themselves or convince others. Fine when it offers some kind of solace or perspective on life. Not fine when it costs people their freedom or their live.
I don't see how that follows. "Religion" doesn't just make the claim that there is a creator and leaves it at that. In fact I'd have more respect for religion if it did.
Take a look at the kind of criticism the ID movement has been getting. Their whole argument is that "something" must have designed the universe. They do not explicitly argue for a God, and some proponents even accept the simulation argument! Nonetheless, Darwinisim wouldn't touch ID with a 60-foot stick.