In other words, I doubt anyone is explicitly penalized for submitting to PLoS Biology instead of Journal of Neuroscience. However, there is an implicit penalty for not submitting to Nature/Science/Cell.
[As an aside, I really hate the obsession with IF and all these other "quantitative" measures of research quality. They're all incredibly ad-hoc, someone easily game-able, and yet otherwise-smart people take them so seriously.]