Whatever you're looking to donate to, Charity Navigator[0] is a good place to look for highly rated charities. If they have a good rating, they're probably good.
Also if anyone is looking to donate to a charity that gives 100%, aka a pass-through charity, I started one for my friend and his family last year[1], as they have an unknown genetic disease which has symptoms related to ALS, Muscular Distrophy, and several other symptoms.