Not related in any way, Little Flocker[0] is a similar program but for file access. It's a little rough around the edges but has been improving steadily.
Edit based on gumby's response below: can it stop finder from littering in every directory it sees?
Spotlight maintains its own database in /
# remove any .DS_Store files
# (run in a subshell to suppress background job number info being printed)
( ag --hidden -u -l -g '\.DS_Store$' |xargs -n 1 rm -f & ) > /dev/null 2>&1