If I build hand made products from my garage and sell them online for example:
1- make up a new word based on a word that best describes your business (e.g. Maker = makr)
2- if taken, look for synonyms of that word and repeat step one (e.g. Craftsman = krafsman)
3- if taken, repeat 1 and 2 with a combination of 2 words (e.g. HomeMade = Homade, etc.)