On the subject of abortion and drugs, it's fairly straightforward. ACLU is not a "states' rights" organization. It is an "individual rights" organization. It sues states for infringing people's rights as much as it sues the feds. So from their perspective, if they can enshrine the protection of a right at a federal level, they'll go for it, because it's easier than forcing all 50 states to do the same.