For Clojure, starting `lein repl`, takes 16 seconds on my 2012 Macbook and 9 seconds on my similarly-aged Dell laptop, both with SSDs and i7 quads.
Regarding memory usage examples, the base memory usage of a Google App Engine instance running the move trivial Hello World Java program takes around 140MB. Given that the default F1 instance has a soft memory limit of 128MB, it becomes clear that the JVM is working against you in both cost effectiveness (the price to spin up new instances as your existing ones are already above the soft limit) and latency (since spinning up instances is slow). Add Clojure on top and the problem certainly doesn't get any better. As an added annoyance, which is specific to App Engine but a result of using the JVM, it's impossible to specify JAVA_OPTS, so any of the -X flags, without switching to the Flexible environment.
As a result of both of the above, choosing Clojure for developing on App Engine, as my specific example, has had the serious downfall of slow development tools and memory issues out of the gate on my instances, causing me to pay more for a beefier instance class. The REPL is really hard to beat, but the combination of JVM and Clojure are the biggest pain in the ass, with this stack.