If it's not physical, it's probably not observable, and science deals with things that can actually be observed. If it is not physical but observable... by what means does it affect actual matter? Neurons have to be coaxed to fire somehow, and if there's a nonphysical spirit poking them then that breaks physics.
Resorting to a nonphysical explanation doesn't explain anything or help you predict anything, so scientists aren't interested. Once they've have ruled out all possible physical explanations then maybe they can give up on them, but it's a long way to go.