My grandmother shits and pukes blood if she takes NSAIDs of any kind, from long-term, daily misuse. I'm not exaggerating even a little bit, I wish I was.
A direct result of being denied access to proper pain relief, mind you, mainly because she lived her entire life without health insurance. Until she turned 65 and qualified for Medicare last year. I had to take every NSAID out of the house, and throw them away, because every time she ran out of opiates for pain relief she'd over-compensate with a handful of NSAIDs which resulted in some scary events, including coffee ground bowel movements which were in fact blood from her stomach. As well as constant vomiting, etc.
My grandfather is similarly damaged from being recklessly over-prescribed NSAIDs, namely 800mg ibuprofen up to 8 times per day, resulting in shitting and puking up blood. He can't have more than an 81mg aspirin now.
/anecdotal evidence