Mostly, I hope they mostly improve the game. Not remake it, re-think it, re-purposed. Just clean it up, make some UI improvements.
If I were to make a big change, it would be to add a stand-alone server. Not necessarily multi-player, but just something I can leave running and attach to. I have an itch for real-time missions (days and weeks long), plus I'd like to run multiple scenarios at once.
I guess what I'm saying is I hope Take-Two doesn't lose the _spirit_ of the game. It has let us ground-bound wanna-be rocket scientists the opportunity to play.