Haskell/GHC will soon have an extension for linear types, which will bring the languages much closer: http://blog.tweag.io/posts/2017-03-13-linear-types.html
This is because, believe it or not, Haskell is actually used in the real world and people care about their code not becoming broken.
Pre 1.0: every day
Post 1.0: not really, though I guess it depends on your definition of "large scale"; we've made some soundness fixes, but made sure that they were warnings for a long time first, so most people experienced no breakage.
Haven't sunk a lot of time into it yet to be honest, I think the biggest beneficiaries will be streaming libraries and non-gced data structures like long lived queues?