My docker-compose always has these three containers: Node (for server side rendering), Python (for APIs) and PostgreSQL.

For the frontend, I use React + Redux + React-Router + Redux Sagas (I like starting with a modified version of ReactGo: https://github.com/reactGo/reactGo).

For the API, I use Flask + SQLAlchemy.

I've been thinking about replacing Python with something more strictly typed (Python 3's hint are a good step, but not enough IMO). However, SQLAlchemy is so great I can't imagine developing without it :)