It destroys "walkable" spaces and encourages centralization of services, when a more uniform spread of services across space is in fact healthier.
I heard of a study recently that showed that cities in Japan that ended up getting Shinkansen stations ended up almost always shrinking, because people got used to going to Tokyo all the time and ended up just moving there. You see similar centralization in places like France (everything goes through Paris)
I realize your point but food deserts exist for a reason.