There's even a couple of kernels for IPython/Jupyter.
The best I've seen so far is
https://github.com/Calysto/calysto_hy
I'd like to move to Hy for much more of what I currently do in Python, but so far I've been too lazy to find/create good editor support for it. For actual projects of some size the loss of context help, documentation, various completions, etc seems like too high a price to pay.