1. Change the layout of modifier keys from Control-Windows-Alt-Spacebar-Alt-Menu-Control to Windows-Alt-Control-Spacebar-Control-Alt-Windows (bind the outermost modifier keys to Super and Hyper if you use Emacs). This will let you do keyboard chording easily with either hand and eliminate "Emacs pinky": https://retrocomputing.stackexchange.com/questions/495/what-...
2. Change Caps Lock to Backspace (RUB OUT on Lisp Machine keyboards)
3. Swap parentheses () for square brackets []
[1] Not on OS X though. Apple does not provide a way to do these remappings on OS X, and breaks the keyboard internals and consequently third party tools like PCKeyboardHack/Karabiner with every OS X release. I tried early this year with Sierra and Karabiner-Elements and this did not work. Install Linux or OpenBSD.