To allow better left-hand-only operation, and to avoid having to move the left hand from the "gamer claw" up to ESC and back. This is part of a larger initiative of mine - to use gaming technologies to improve business performance. In menus, the lower right button becomes a "nope" button.

But you're right about F2, and I honestly never use it. But I haven't thought of another button to replace it with - maybe Ctrl-V, and F5 with Ctrl-C? Hmm...I'll have to test this out!