I always consider intellect to be a part of the nature.
It is a nature's way to reason about itself after all.
But in another sense, intellect vs nature is a useful distinction to make.
(E.g. blind forces of evolution through selection/mutation/etc, vs conscious targeted changes).
Human knowledge in general might, but I'm talking about how humans take action and shape the world around them vs how evolution does.
Conjecture and refutation are not like random mutations -- that's just the "survival of the fittest" part of evolution, which is not the actual mechanism and which applies to everything (after all, anything that survives is fitter that what didn't).