We've updated the title from “Dietary sugars, not lipids, drive hypothalamic inflammation”, which sort of plainly doesn't follow the conclusions of the study.
Since they only tested LCHF and HCHF, the High fat part is the control, leading to the logical conclusion that the high carb part is responsible.
The new title is probably a bit misleading since they didn’t test Low carb low fat, so you can’t conclude that it’s the combination of HCHF, at least not with this study.
That seems consistent with the original title that sugars cause inflammation, no?
According to the results section they also did not evaluate the hyperthalmic microglial activities of the Chow (HCLF) diet so it’s unknown from the paper if If the high carb only diet had detrimental results.
Wish I could ask the authors about these holes.
> Combined overconsumption of fat and sugar, but not the overconsumption of fat per se, leads to excessive CML production in hypothalamic neurons, which, in turn, stimulates hypothalamic inflammatory responses such as microgliosis and eventually leads to neuronal dysfunction in the control of energy metabolism.
We've been so poisoned by bad science that it's hard to come to a consensus on anything.