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I've just checked the "drug response" section in my 23andme.com data, but I don't see anything about provigil.

Searching for rs4680 did show a result though (I have the AA variant).

This means, like me, you have a Valine codon in place of a Methionine codon in your COMT gene at codon 158. This means the enzyme catechol-O-Methyltransferase which breaks down catecholamines like dopamine/norepinephrine has reduced activity and less stability, resulting in increased catecholamines in some areas of the brain.

I recommend downloading your raw data from 23andme and using the prometheus program from SNPedia. This is how I found out about this gene. This program is very raw but includes a lot more research and points you to the relevant papers.

Keep in mind, this information is all AFAIK, as I am just browsing this information casually.

> prometheus

http://www.snpedia.com/index.php/Promethease

(edit) Oh, it's a crippleware. They want "optional $2 payment" so that the program would run in 5 minutes instead of 3 hours. How cute.

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