I use Tufte CSS stylesheet (very slightly modified) on my blog/static generator. I like it for its focus on plain text and clarity over flashy presentation. Some people have complained about the font - serif fonts are out of style on the web but I find it easy on the eye.

The biggest problem I have found is that it really doesn't have a great answer for vertical mobile screens. It works, but I find the layout sub-optimal. I decided it was acceptable though.

These two posts demonstrate what I was going for the best:

https://sheep.horse/2017/9/crossfading_photos_with_webgl_-_b...

https://sheep.horse/2017/10/how_you_are_reading_this_page.ht...