TechZing gets my vote. http://techzinglive.com/
It's broadly about issues relating to tech startups but meanders quite a bit. The hosts are characters and it doesn't take itself too seriously.
By the way, for anyone interested in checking out the TechZing podcast, we not only discuss tech, startups and other HN-like topics, we'll even on occasion take a risk and venture into the unknown. For example, we recently interviewed a historian of UFOs and the national security state which, to our surprise, turned out to be one of our most popular shows of all time.
This week we're interviewing David Fogel, who evolved a world-class checkers playing algorithm named Blondie24, and I anticipate that to be an especially interesting show.
Anyway, you should listen to us here: http://techzinglive.com because if you like HN then you'll probably like our show.