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We'd have to be totally separated from those colonies for an unthinkable amount of time for stuff like that to happen - I'd imagine we'd at least keep contact with our own colonies and the Native Americans were largely separated from Eurasia for thousands of years and crazy stuff didn't happen aside from a gap in immune system prep.

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Not with the distances and times involved unless we develop FTL communication. At first we may not diverge biologically, but culturally, and that is quite enough to close most doors... after all how many Norwegians do you find that marry bushmen or aborigines and vice versa?

A lot of sci fi seems to somehow overlook our cultural/social baggage and yet those are precisely what are crippling us now, and likely to retard our progress in the future too, if not outright destroy us.

Earth would keep contact with colony A which would be slightly different. Colony A would keep contact with colony B which would be slightly more different. It would only take a few tens of hoops to get to something different enough that would classify as alien. At interstellar distances, this is a definite possibility. Isaac Asimov's empire, foundation and robot series have some fascinating (hypothetical) examples of this.

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