And the post previous is right. Climate change is the big one. It affects the entire planet.
However the, for a better word, desocialization of the USA is also a big factor both inside the country, and outside of it due to people who associate with or are relatives of americans being affected, or resources that would be used to help improve situations in other countries being tied up with emergencies in-country that would otherwise be handled by funds that are now going to tax breaks.
Then there's also the situation in Yemen which the USA is indirectly responsible for. And there's the situation in Puerto Rico, which is nominally american, but i think if a people don't get to vote, they get to be counted as a different country.