“I was disappointed that the iPhone wasn’t... a phone that ran Mac software.”

What? I admire Dave Winer’s idealism, but really?! Would anyone else enjoy using the full Mac OS X interface on the iPhone? (Ignoring the iPhone’s performance and power limitations, which negate this possibility.)

Does he really want a phone to run applications that were designed for much larger screens, with mice and keyboards?

If you know how to write a Mac app, it’s not a terrible leap to write an iPhone app. If you want compatibility with Mac apps, look for iPhone apps like OmniFocus, Things, &c. that have been retooled for a mobile use case. If anything, the iPad comes closest in this regard, with some of it’s near-desktop-class apps, e.g. iWork, OmniGraphSketcher, OmniFocus, OmniGraffle, &c.