It depends on how much work you want to do... I change umatrix defaults to not allow any javascript, which breaks a lot of things (usually images :/). I also don't load anything from third party sites by default, which also breaks images and often css (many sites I usually just read the text with broken css). For this uMatrix is great and I wouldn't use uBlock Origin at all except that uMatrix has no option to not load fonts and I also have Firefox configured to just use DejaVu 16pt on all sites (which makes the web so much nicer, although also breaks a few things), but this doesn't prevent it from loading fonts for some reason (at least last I checked). I guess because some sites use icon fonts and maybe Firefox can't tell the difference until it gets the file.