Surely the simplest solution to the reproductive question during space colonization is to send along a doctor or midwife with the couples headed out from earth?
Humans are really good at making this happen.
From this perspective, there may be some merit to the parent poster's argument that human "factories" may be less risky for everyone involved, since it might be easier to control the conditions.
Which is very, very different than sending pregnant humans into space.
>>Long term more serious issues are space radiation effects.
Not just that. Muscular degeneration is a real problem, especially (in this case) for humans who have to carry a child inside them.