Informix is a pretty great database. Much like you mentioned with DB2, it can take really varied workloads on the same database and keep on trucking. Just requires some basic indexing, no need to carefully tune to a particular use case.
The best part is how resource light it is. I was using Informix on a dual 200mhz HP K class box until about 8 years ago. HP literally just gave us a RP3440 to get us off it...