Using senolytics is also trying the brute force approach.
And what about targeting the level of cytokines? The immune system is sometimes running on free wheels (aging, autoimmune, etc)
Let the body regulates itself.
And what about targeting the level of cytokines? The immune system is sometimes running on free wheels (aging, autoimmune, etc)
Let the body regulates itself.
Senescent cells are one of the root cause of aging. Signaling changes in old blood are downstream of the root causes of aging - secondary and later consequences.
Senescent cells are created by the operation of normal processes of healthy, youthful metabolism, and if their numbers can be periodically culled, then their contribution to aging will be removed.
If your car is flagging, you repair the engine by replacing a damaged part, not by pressing the accelerator harder. Removing senescent cells is replacing a damaged part. Overriding signaling changes is pressing harder on the accelerator, while ignoring the damage.
Removing != replacing. What are you replacing the senescent cells with?
Replication from where though? The tissue stem cell that has already divided too many times?
In that case your plan would be treating the symptom, not the cause (accumulated genetic errors and whatever other junk in the stem cells). I would also expect it to lead to cancer.