However, by default, nonsensical operations should not be possible.
I haven't seen that in ARM microcontrollers, but as peripherals vary across manufacturers I don't think you can assume that it's not done this way.
If there are multiple chips connected in open-drain, you write the I/O pin to 0 or 1 to either ground or float the pin. You read the I/O pin to see if anyone else has grounded it if you haven't. This was called "wired-OR" in the old days. (It's really AND, but was commonly used in DeMorgan equivalent form for communication buses before tri-state drivers became a thing. I'll get my cane and hobble back to my rocking chair now..)
In other cases, you want to avoid glitching when the pin switches to an output on startup.