2018: Bitcoin goes full bubble. You'll have more mainstream experts implying it will hit $1M. The more technical people will pull out entirely or try out altcoins. Bitcoin has a limited window to step up their game. Possibly see ETH take over or even Bitcoin Cash.
It would either be year of the altcoin or crypto crash.
Longer term: Increased H1B restrictions and high Silicon Valley land prices would make investors look for alternative cities for early stage investments. It's unlikely this city will be in the US.
Also I foresee "startup" not being a buzzword anymore, replaced by "side project".