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Comment by Eilene | Hacker News Reader

Peter said he thought he needed modafinil. Why is it a hot topic now? His thought way back was that it was everything he needed at the time--mood regular, stimulant.

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It said to have characteristics of a holy grail stimulant: increased performance without the crash or heavy tolerance build.

That’s an odd assertion to make when the full pharmacodynamics and mechanism of action are unknown. Modafinil doesn’t increase your cognitive performance in the way that a substituted phenethylamine would. Focus and attention are certainly related to wakefulness, but wakefulness in and of itself doesn’t increase cognitive performance.

Can you tell me what substituted phenethylamine is?

Substituted phenethylamines[1] are derivative compounds of phenethylamine. Many substituted phenethylamines are stimulants, while some are psychedelic too. Dopamine, epinephrine, amphetamine, pseudoephedrine, MDMA, and many others are considered to be substitued phenethylamines.

[1] https://en.wikipedia.org/wiki/Substituted_phenethylamine

No crash might be the problem with it: you try to go to sleep and end up just kind of laying there half the night.

Modafinil interferes with sleeping less than other drugs - it's only a problem if you rely on the "crash" of running out of energy over the day to fall asleep.

it's heavily dependent on the right genetic makeup from what i know.

for some it provides clarity, for others, fog. the dopamine transporters are very mysterious to me.

regulator, sorry.

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