A good recent paper on sources of inflammation in aging:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850851/

As it points out, the most obvious and promising of current prospects for reducing inflammation is the selective destruction of senescent cells. Though I think that the clearance and recreation of the entire immune system, to remove all of the senescent, exhausted, misconfigured, etc, immune cells is also a promising path, albeit further away from being safe enough to apply to old people.