The combination of nutrients in food can have a large effect on the efficiency of nutrient extraction in your stomach and gut. For example, when you consume alchol and a meal afterwards your body will store more fat than if you'd just taken a (slightly larger) meal. This is because your body will prioritize burning the acetate and alchol over anything else (including carbs, fat and protein). Other foods or chemicals might have effects on the resource burning allocation of your body.