What exactly do you think it mean for someone's experience of discomfort to be "unreasonable"? And why do you think that justifies taking actions that we know are likely to cause someone else discomfort?

I can't say I find your examples particularly justifying. I think we should leave agoraphobic introverts alone if that's what they want. I think sales and advertising are obnoxious and society would be better without them. And I think people should be free to explore different views at their own pace, as long as they're not hurting anyone. Or if they are hurting someone, then that discomfort caused by challenging their views is justified, but it's still a bad thing in itself.