wxPython is a thing that exists, and I believe it has a similar mental model to wxWidgets.

To be honest most of the QT solutions for Python are pretty fidgety . The recent wxPython releases (4.x) work out of the box direct from PyPI, not too much to worry about licensing.

For Qt, it's... the licensing is usually just fine for people but it's complex enough to where things like maintaining your own fork (pretty easy in Python compared to C++) is not super easy. But there's decent Python support, so it's more "do you want to use Qt or wx". Both systems have good enough support.