No, but you can use an extension/native helper and talk to it from the web app using network calls.
For example, Postman (browser-based HTTP client) has some of the worst UX because it's a Chrome app and not stand-alone. Can't event alt-tab to it. I have to alt-tab to Chrome and then find the Postman window.
Can we, instead of combining the worst of native apps, web apps and containerizaton, maybe work towards removing SOME of the terrible aspects for users? If developer comfort is the highest priority you might as well skip making the interface look nice/useable.
Electron really is an extension of Chrome and it'd be damn nice if it could be shipped as one.
I've created Electron application also, not because it's the best solution on the market but because it was fast and easy way to get my app to the users.
If I had time and resources I would probably just use Qt or created native app for each platform.