They're addressed by established process and routine - 2 things machines do better than us. Can a machine monitor braking or perform the current brake check - absolutely. Could we shift the responsibility of check the load tie-down to the freight facility and monitor ongoing status with sensors. I'd hope so.
You should be asking "can a robot drive for 12+ hrs without fatigue?" or "can we eliminate the restrictive, expensive and often gamed system of keeping drivers within their hours?" This is were long-haul transport could be "disrupted"