One main class comprises tryptamines (e.g., DMT and psilocybin) and other serotonergics (e.g., LSD). They seem to mess with mainly sensory and meta-sensory (or self-sensory) stuff as serotonin agonists. Another main class is phenethylamines aka amphetamines (e.g., Ecstasy and other MDMAs). They alter mainly body-related states, such as alertness, emotions and pleasure. Mainly by stimulating release of serotonin, dopamine, and noradrenaline.
Edit: deleted a stranded stub
I wonder if this temple will be renting out its rooms for DMT trip events.
The hallucinogenic similarities may be due to a similar chemical reaction to the drug between human brains -- not necessarily a higher entity.
It really is an interesting drug though, and I would agree that it deserves further investigation.
This is literally going to be true whether or not a higher power is involved. Our brains are the chemicals either way.