I contribute to an effort to run a clinical trial for applying statistical models to drug-resistant epilepsy, for patients who will undergo surgery. The results are complex both scientifically and morally. We saw a patient undergo a "failed" surgery in the sense that seizures continued but GPA shot up to 4.0. That patient is coming back for another surgery, but clinicians aren't sure what to do. Not to mention that total cost is something like 50k+ euros: what other pressing problems could be solved with a large budget?

Outside of invasive neurosurgery, it's also difficult to draw the line between stimulation & behavioral protocols, which can rewire the brain, that are good and those which are bad (for whom? by what metric?). The questions have little to do with neuroscience imo.