Can we update the title to reflect the research by adding "in mice" at the end of it?
The effect of calorie restriction on aging in rodents has been known since the 1930s. Which does not diminish the value of identifying the precise molecule that triggers this, but it does mean that this shouldn't necessarily be used as justification for a fasting diet.
"It has been known since the 1930s that reducing the number of calories fed to laboratory rodents increases their life spans. The life extension varies for each species, but on average there was a 30–40% increase in life span in both mice and rats.[30] In late adulthood, acute CR partially or completely reverses age-related alterations of liver, brain and heart proteins, and mice placed on CR at 19 months of age show an increases in life span.[78] "