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I recommend notmuch in place of mu/mu4e and msmtp in place of a full-blown smtpd implementation.

I also recommend isync's mbsync over offlineimap

Agree with using Isync. Notmuch lacks the backward synchronization to the IMAP server and to another mail client then notmuch.

I primarily use mu4e but want to see changes on my mobile as well as on any remote computer using a web client in a browser.

As far as I know notmuch can just be synchronized to another notmuch instance.

If you use https://github.com/gauteh/gmailieer you can have bidirectional sync between gmail tags and notmuch tags.

Personally, I don't bother with it. When I have to do mail on my phone, it's usually so limited in scope that I don't need to retain state when I sit down at my main computer. I can imagine that's not for everyone, though.

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