You can fail, pick yourself up, and try again. You can increase your probability of doing good, and accept the tradeoff WRT business success.
I should add that I think Paul presents a very clear vision of why he thinks this is not a problem: his mantra about finding a problem a real person needs solved and solving it (substitute actual quotation here). My objection is that where this leads you is to unexploited niches in the market ecosystem -- returning to Tim's language, to focus on capturing value rather than creating it. I suspect Paul tart rejoinder would be that a happy customer is much better evidence of value created than fuzzy dreams of do-gooderism are. I believe he is partly wrong. I hope he will speak for himself on this topic.