Python 3 might occasionally require some extra steps when consuming strings compared to Python 2, but the reality is that those steps were always necessary. Python 2 just hid those details in a way that was only really safe for english-exclusive development. That doesn't mean that Python 2 is easier to use or less brittle. In fact I would say it means the opposite.
Last unicode issue I had was on a system german characters, because some library assumed it had to explicitly perform encoding with a bad default setting. If the library didn't try to be smart the program would have worked independently of system or language, instead it failed on any non english system by trying to convert a perfectly fine, system specific encoding to utf8.
The NHS chose not to upgrade to from Windows XP and 2003 and look where that got them last year: a massive crypto locker infection.
All interchanged Unicode text should be UTF-8, never use another encoding* (without a really compelling reason).
No, storing it as an array of unicode characters isn't a compelling reason during interchange.
ALSO, never use a BOM; that will break things.
The second answer (should be anchor-linked) in this goes over MOST of the advantages of UTF-8, but it doesn't capture that some carefully input operations in otherwise completely Unicode //unaware// 'string' functions result in no change to string validity.
The only potential issue is if recognizing something in different normalization representations is important. However, for nearly all quick and dirty tasks (where a short script is most likely) it usually doesn't matter. For everything else a different paradigm than the one Python3 picked would be better. (One where adding filters to a read file is OPTIONAL and they can be invoked on individual byte-strings as well.)
https://stackoverflow.com/questions/6882301/what-is-the-best...