I have experience, and it happened well before the iPad.
I have a Lenovo X61 notebook/tablet w/Pen. Combined with Microsoft OneNote it allowed me to take notes on my computer, even in my engineering classes.
For a while I had experimented with taking all of my notes with a plain laptop since I can type much faster than I can write with the added bonus of not having legibility issues.
For some classes this worked just fine but being an engineering student, it ultimately proved impossible. Try taking physics notes, at speed, with Word and it's equation editor and you'll get it pretty quickly. Trying to keep a notebook of paper diagrams and typed notes on my computer synchronized was also proving to be a pain.
Then my laptop died and I purchased a Lenovo X61 tablet. It changed everything.
Being able to type notes in a lecture then flip the screen over and start copying over diagrams drastically increased my efficiency by reducing everything to one medium. I could now do typed notes, hand written notes, homework assignments completely on my computer and even in one program. The only paper I relied on was printing some assignments as needed.
Conversion tablets have been around for a while and have both a touch screen and a keyboard, allowing for a very wide range of user input. Coupled with programs like OneNote and some diagramming/mind-mapping software I can quickly sketch out just about anything I can think of.