I used to do that in Common Lisp, which has the only FFI I've come across that's even nicer than Python's. But it's backwards; once you're in a high level language, it's inconvenient and expensive to reach down.

It makes a lot more sense to me to drive the whole process from C; not only do you have direct access to C; you also get to control the embedded world from the outside, which is about as meta as it gets.