It would be great to see an HTML minifier in F#. I've thought about building one as a way of learning the language. An F# based static site generator, similar to Jekyll or Hugo, would also be neat.
Compilation of F# is a confusing story to me. If it's still compiling to an IR, and getting JITted at runtime, that seems kind of inefficient in a world where Go exists. There's the CoreRT project, I think, that allows for precompiled .NET applications, but I'm not sure how F# fits in. I also read that all Windows Store/UWP applications are precompiled on Microsoft's cloud. I'm curious about compile-time flags and optimizations for F#, but they're rarely mentioned.