In 2016, an explosion at a single industrial gas facility caused a whipped cream shortage in the US. [1] I mean in the scheme of world problems, that's one we'll survive, but it does illustrate how vulnerable a lot of our supply chains are.
In 2007, the shutdown of the Canadian Chalk River reactor caused worldwide shortages of isotopes used for medical imaging, with real life consequences for patients. [2]
There are probably countless other examples. In the end, its the direct consequence of the constant quest to lower production costs and increase efficiencies.
[1] https://www.theatlantic.com/science/archive/2016/12/the-dead...
[2] https://www.nytimes.com/2007/12/06/business/worldbusiness/06...