A reverser only redirects thrust, and only generates about 60% of max thrust pushing backwards.
It's only on for a limited time on the ground because under a certain speed, you run the risk of blowing FOD into the intake path, putting the engine at risk.
I'm not aware of any reason to outright lockout a reverser in flight other than to hedge your bets against a very, very poor set of configuration choices by the pilot (reversing near stall speed too low to recover). I could foresee scenarios where being able to use reversers in the air could save the aircraft with the right combination of subsystem casualties.
Not a pilot or engineer, but absolutely LOVE aviation.